Treatment of mesothelioma--Biological therapy

Biological response modification therapy

Biological response modifiers ( BRM) is the body's own cells and a number of elements, both inside and outside of the body response to environmental stimuli, and to participate in the maintenance of the stability of the local environment in the body. BRM through the body to mobilize the inherent ability to resist and eliminate the tumor, the treatment of tumors become a new model. With the cell engineering and genetic engineering progress, BRM in the field of cancer therapy has great development potentials. Cytokines interleukin-(IL), interferon (IFN), tumor necrosis factor (TNF), etc. In addition to direct anti-tumor cells, and cancer cells in the body activated, secretory or anti-cancer effects of molecules, cells or maintain the immune response Proliferation and differentiation of functions, the PMM can be used as adjuvant therapy. Adoptive transfer of the collection of immune cells, isolated cancer cells in the ascites, in vitro amplification, and induced activity of the anti-issued lymphokine activated killer (LAK cells), will be injected into the body, anti-tumor cells. At the same time, given IL-2, may enhance the effectiveness of treatment. Tani [16], and so will the patient's own cells and malignant mesothelioma cells mixed culture, to be anti-CD3 monoclonal antibodies and the activation of IL-2, to generate cytotoxic T cells (CTL). CTL activation of their own malignant mesothelioma cells have a high degree of cytotoxicity. PMM to the author of 2 cases of patients with chemotherapy at the same time, intra-abdominal injection CTL as adjuvant therapy, the results of ascites subsided, the gradual disappearance of tumor mass, and improve the quality of life of patients. PMM rare for the conclusion of peritoneal cancer, has always held that the very poor prognosis, so far there is no standardization of treatment. However, the situation is expected to change. In recent years, mainly to surgery, chemotherapy, radiation, immunotherapy combined therapy has been