Diffuse malignant pleural mesothelioma pathological changes
Diffuse malignant pleural mesothelioma along the pleural surface, can occur in the wall, the visceral pleura and mediastinum. It is difficult to distinguish the origin of lesion site. CHANG tumor interstitial lung direct invasion to form a nodular mass. Mostly gray tumor, as a result of some of the local necrosis and yellow, hard texture. Often transferred to the hilar and mediastinal lymph nodes, blood can also be transferred to the lungs, liver, brain and adrenal gland. As the skin between the histological diversity, and therefore its histological features and more complex classification. Generally be divided into E-, sarcomatoid type (fiber type) and three types of hybrid, often more than skin type. Single-use optical microscopy often difficult to E-malignant pleural mesothelioma and metastatic adenocarcinoma of the lung, and so the distinction. By immunohistochemistry and electron microscopy help to identify. Malignant pleural mesothelioma low-molecular-weight cytokeratin staining positive, can be separated and sarcoma; malignant pleural mesothelioma can not be CEA (CEA) stain, which can be differentiated adenocarcinoma. If the results of immunohistochemistry with the same tumor, electron microscopy can generally be confirmed. Malignant pleural mesothelioma of the most prominent feature of many of the curved microvilli, and adenocarcinoma microvilli short and straight, and the top covered with a layer of polysaccharide protein complex.