Mesothelioma examination--NOR AgNOR

NOR AgNOR (agNOR) inspection

agNOR reflects the proliferation of nuclear activity. Research in recent years that ag-NOR different characteristics (the number, size, distribution) of benign and malignant lesions in the differential diagnosis of a certain value. Wu Xia, such as 12 〔〕 study found that malignant mesothelioma with the reaction of mesothelial hyperplasia as the main difference between the two: ① malignant mesothelioma agNOR particles of the total average 4.26 ± 1.28, reactive proliferation of mesothelial cells to 1.28 ± 0.38; ② malignant mesothelioma cell nucleus containing 1 or 2 particles, an average of 4.42 ± 1.20,2.38 ± 0.38; reactive proliferation of mesothelial cells were 1.28 ± 0.31,1.7 ± 0.48; ③ malignant mesothelioma agNOR particles inside the nucleus Diameter ≥ 2.6μ m, accounting for 84.33 percent, the response of mesothelial hyperplasia accounts for only 0.48 percent. These three indicators can be used as identification of malignant mesothelioma with the reaction of mesothelial hyperplasia of the objective basis. However, benign and malignant mesothelium cell count average agNOR have overlapping areas, such as ag-NOR particles 0.6677μ m2 area as a benign skin between the upper limit, the specific diagnosis of malignant mesothelioma of 100%, 63.8% sensitivity; EMA and combined, the sensitivity can be increased to 95%, and there are very few false positives 〔〕 9. Recently, the use of quantitative image analysis, the method is fast, accurate and objective advantages. As benign and malignant mesothelium cell differential diagnosis of an auxiliary diagnostic method.