Mesothelioma examination--Optical microscopy

Optical microscopy

Pleural mesothelioma is a rare tumor, but its incidence in recent years there has been an upward trend year by year. As the skin between the multi-functional differentiation potential of causing a variety of malignant mesothelioma cells, in the light microscope with pleural metastatic adenocarcinoma, reactive mesothelial cells and other spindle cell tumor is not easy to identify, to the clinical and pathological diagnosis work with To the difficulties. In recent years, as a result of pleural mesothelioma awareness and raise the level of electron microscopy, immunohistochemistry technology, so that the diagnosis of pleural mesothelioma level has been greatly improved.
An optical microscope
Due to the diversity of mesothelioma cells, light microscope, histological type of malignant mesothelioma is not uniform. The World Health Organization had diffuse malignant mesothelioma (dMM) into E-, and mixed sarcoma. 1 〔〕 adams, and so on in accordance with pleural dMM autopsy material into the cell-like tumor type, papillary type tubular, sarcoma-like, mucus-like, hard-and fiber-like hybrid. And in the diffuse pleural tumors, such as found in tumor cells produce collagen material can be identified as dMM. Otherwise, should the existence of small intracytoplasmic vacuoles and even light to moderate nuclear / plasma ratio. Key in the country, such as 2〕 According to the arrangement of the tumor cells, the tumor cells and a different tumor cell components account for at least 50% of the tumor is divided into 11 types: tubular-like type, papillary type tubular, undifferentiated , Fibroblast-ring-like cells, mucus-like, myofibroblastic-like cells in lymphoid tissue type, blood vessel cell type, small-cell and hybrid-type cells. And that help from the following aspects of light microscopy diagnosis of the tumor: ① combination of the tumor occurred in the special position; ② search for a two-way tumor differentiation, especially when the suspected tumor should be more based on observation of production; ③ tumor cell migration phenomenon in transition ; ④ a variety of different types of tumor cells mixed exist; ⑤ clinical performance of the critically ill, but the tumor cell nucleus split as rare.